In the face of the failure of both traditional European Sinology/Japanology and North American Area Studies to overcome anachronistic nation-centered methodologies, this article calls for a new East Asian Studies in a globe-spanning and comparative key, as part of the emerging Global Humanities. It illustrates ways to push for a new regionalism in East Asian Studies, in the overall frame of our shared global condition, and aims to empower the concept of the “region” as a unit of human experience and state-building, transcultural encounters and knowledge exchanges, and a zone of proximity and close difference that provides an alternative to essentializing notions of “cultures” or “civilizations” that could be academically incommensurable and incomparable or militarily and socially “clashing.”As a case study the article explores the rise of modern, Western-style literary historiography in East Asia, a process that has so far only been analyzed separately in Japanese, Chinese, and Korean studies and thus not been understood in its historical significance and complexity. The article proposes new tools for understanding the rise of this genre in the context of the emergence of the modern Japanese empire in the region, typologizing literary histories into “idiographic,” “heterographic,” and “xenographic” ones, written, respectively, on the historiographer’s own, a culturally related, or completely foreign literary tradition. Ultimately it aims to illustrate the need for a regionally-focused, globally framed, understanding of East Asia and also to showcase how a new focus on comparative studies of premodern macro-regions can help developed more nuanced methodologies for our understanding of the diversity of human culture.